ABSTRACT

Objectives:

The aim of the study was the evaluation the data of patients with early onset schizophrenia (EOS) within the scope of the Revolving Door Phenomenon (RDP).

Materials and Methods:

Data obtained from three child and adolescent psychiatry inpatient services in Turkey were retrospectively evaluated and sociodemographic characteristics, psychiatric comorbidities, treatment modalities, pre- and post-treatment assessments of the patients were assessed with the Positive and Negative Syndrome Scale (PANSS) and Children’s Global Assessment Scale (CGAS). Patients with more than one hospitalization within 18-60 months of follow-up from the admission to the study were evaluated, and patients with two or more hospitalizations were accepted as RDP (+).

Results:

Between RDP (+) (n=40) and RDP (-) (n=35) groups, a significant difference was found when only history of substance use disorder (p=0.007) was compared in terms of sociodemographic variables. When the psychotropic drugs used during their hospitalization were compared between the two groups, differences were found in terms of haloperidol (p=0.001) and First Generation Antipsychotics (FGA) (p=0.011). The findings showed a significant interaction between the number of hospitalizations of patients with 18-60-month follow-up defined for total PANSS hospitalization scores (p= 0.044) and CGAS scores (p=0.006). In the regression analyses, it was found that the history of substance use disorder, FGA use and total PANSS scores of hospitalization were significant predictive factors for RDP in patients with EOS.

Conclusion:

In our study, findings suggest that personalized strategies focusing on early identification of clinical dimensions, evaluation of substance use disorder history, and treatment management of cases may help reduce the effects of RDP.

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The “Revolving Door Phenomenon” in Patients with Early Onset Schizophrenia: A Multicenter Study

ABSTRACT

References