Abstract
Selective serotonin reuptake inhibitors (SSRIs) are preferred over other antidepressant drugs due to their low anticholinergic and cardiotoxic side effects. Although SSRIs are regarded as safe drugs, they may have some severe hematologic side effects. Neutropenia is one of the rare and transient side effects of antidepressant drugs. In this report, a case of sertraline induced neutropenia was aimed to be described. Although sertraline is a widely used antidepressant in children and adults, neutropenia induced by this drug is very rare. When all data were evaluated, since the case had no history of any medical illness that might have caused neutropenia and any relevant drug use, neutropenia was associated with sertraline use in the case presented. Thus, improvement of neutropenia after cessation of sertraline treatment further supported this opinion. This case is worth reporting since it underlines the need for considering the increased risk of much more severe hematological side effects associated with SSRI use in the presence of comorbid diseases or use of multiple drug therapy.
Keywords: Selective Serotonin Reuptake Inhibitor, Sertraline, Neutropenia, Hematologic Side Effect
