Abstract
Conclusion:
The research to date has been hindered by methological difficulties and the heterogeneity of autism. Longitudinal studies in autism are needed to confirm a potential defect in neuronal migration, synaptic pruning and apopitosis during early developmental of life.
Results:
Many regions of the central nervus system have been implicated in the genesis of autism, but the neurobilogical basis of the disorder remains unknown. Investigation of central nervus system in autism gived impression of the disorder may be a neuronal circuitry disorder rather than involvement a specific brain region. Neuropathological, neurobiological, biochemical, sleep, structural and functional neuroimaging studies suggested that abnormal neuronal migration, synaptic pruning and apopitosis may play a role in the etiology of autistic disorder.
Method:
Selected papers and books regarding to autistic disorder, neuronal migration, synaptic pruning and apopitosis are reviewed, and the consequences are summarized in presented review.
Objective:
Several lines of evidence support the notion that developmental process may be important in the etiology of autistic disorder. The aim of this paper is to review the neurodevelopmental process and the reported neuropathological findings in autistic disorder that may be a consequence of disturbances in this process.
Keywords: Autistic disorder, neuronal migration, apopitosis, synaptic pruning
