Abstract
Objective:
The aim of the present study were to compare event related brain potentials (ERPs) indices between children with attention deficit hyperactivity disorder (ADHD), and normals.
Method:
ERPs indices, latencies of parietal P3 (PP3L), P1 (PP1L), N2 (PPN2L), and frontal P1 (FP1L), N2 (FN2L), P3 (FP3L), and amplitudes of parietal P3 (PP3A), P1 (PP1A), N2 (PN2A), and frontal P1 (FP1A), N2 (FN2A), and P3 (FP3A), using an auditory oddball paradigm were recorded in 43 boys with ADHD, and in 23 normal children.
Results:
PP3L and FP3L were significantly longer and PP3A, FN2A, and FP3A smaller in children with ADHD compared to normals (all p values <05). No significant differences were found in other ERPs indices.
Discussion:
Smaller P3 amplitude and longer P3 latency in ADHD group may be indicate ineffective working memory updating. Smaller N2 amplitude in ADHD group may reflect an atypical frontal inhibition process. These results suggested that ADHD is associated with frontal dysfunction.
Keywords: Attention deficit hyperactivity disorder, event related potentials, P3, P1, N2
