EN | TR
E-ISSN: 2687-3532
The Evaluation of Amygdala Volumes in Adolescents with Bipolar Disorder Type I
PDF
Cite
Share
Request
Original Article
VOLUME: 26 ISSUE: 2
P: 89-95
July 2019

The Evaluation of Amygdala Volumes in Adolescents with Bipolar Disorder Type I

Turk J Child Adolesc Ment Health 2019;26(2):89-95
DOI: 10.4274/tjcamh.galenos.2019.2019.03.05
Birsen Şentürk Pilan 1
F. Neslihan Emiroğlu 2
Handan Güleryüz 3
Taner Çelik 4
Ahmet Ergin Çapar 5
Hülya Ellidokuz 6
Ümit Şahin 7
Süha Miral 8
1. Ege Üniversitesi Tıp Fakültesi, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Anabilim Dalı, İzmir, Türkiye
2. Dokuz Eylül Üniversitesi Tıp Fakültesi, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Anabilim Dalı, İzmir, Türkiye
3. Dokuz Eylül Üniversitesi Tıp Fakültesi, Radyodiagnostik Anabilim Dalı, İzmir, Türkiye
4. Doruk Özel Bursa Hastanesi, Radyoloji Birimi, Bursa, Türkiye
5. İzmir Sağlık Bilimleri Üniversitesi Tepecik Eğitim ve Araştırma Hastanesi, Girişimsel Radyoloji Kliniği, İzmir, Türkiye
6. Dokuz Eylül Üniversitesi Onkoloji Enstitüsü, Prevantif Onkoloji Anabilim Dalı, İzmir, Türkiye
7. Dokuz Eylül Üniversitesi Tıp Fakültesi, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Anabilim Dalı, İzmir, Türkiye
8. Özel Muayenehane, İzmir, Türkiye
No information available.
No information available
Received Date: 11.03.2019
Accepted Date: 10.06.2019
Publish Date: 26.07.2019
PDF
Cite
Share
Request

ABSTRACT

Conclusion:

The differences detected in amygdala volumes by structural MRI scans in adolescent and adult BD samples may reflect underlying pathophysiologic differences between the early onset and the late onset of the disorder.

Results:

The evaluation and comparison of both right and left amygdala volumes between the patient and the control group revealed no significant difference. However, in the patient group, negative correlation was found between right and left amygdala volumes and the duration of the disorder (for the right amygdala p=0.026; for the left amygdala p=0.031).

Materials and Methods:

Seventeen adolescents aged between 13 and 19 years, who had BD type I according to Diagnostic and Statistical Manual of Mental Disorders-IV criteria that was either already been followed up or got the diagnosis after their admission to Dokuz Eylül University Faculty of Medicine, Department of Child and Adolescent Psychiatry between May 2008 and October 2008, were included in the study. Twelve adolescents between 13 and 19 years old and without any psychiatric diagnosis were included in the healthy control group. The magnetic resonance imaging (MRI) scans of all participants were performed by using an MRI machine with 1.5 Tesla power (Gyroscan Intero, Philips, Netherlands) and standard head coils. The MRI scans of the cases were made during euthymic phase. The phase of euthymia was defined according to Young Mania Rating Scale and Hamilton Depression Rating Scale.

Objectives:

The aim of the present study is to investigate whether the variables of the disorder affect amygdala volumes in the adolescents with Bipolar Disorder (BD) type I and to compare the possible amygdala volume changes with healthy adolescents.

References

1Wilke M, Kowatch RA, DelBello MP, Mills NP, Holland SK. Voxel-based morphometry in adolescents with bipolar diosrder: first results. Psychiatry Res. 2004;131:57-69.
2Geller B, Lub j. Child and adolescent bipolar disorder: a rewiev of the past 10 years. J Am Acad Child Adolesc Psychiatry. 1997;36:1168-1176.
3McElroy SL, Stakowski SM, West SA, Keck PE Jr, McConville BJ. Phenomenology of adolescent and adult mania in hospitalized patients with bipolar disorder Am J Psychiatry. 1997;154:44-49.
4Bromet EJ, Finch SJ, Carlson GA, Fochtmann L, Mojtabai R, Craig TJ, Kang S, Ye Q. Time to remission and relapse after the first hospital admission in severe bipolar disorder. Soc Psychiatry Psychiatr Epidemiol. 2005;40:106-113.
5Mick E, Biederman J, Faraone SV, Murray K, Wozniak J. Defining a developmental subtype of bipolar disorder in a sample of nonreferred adults by age onset. J Child Aodolesc Psychopharmacol. 2003;13:453-462.
6Faedda GL, Baldessarini RJ, Suppes T, Tondo L, Becker I, Lipschitz DS. Pediatric-onset bipolar disorder; a neglected clinical and public health problem. Harv Rev Psychiatry. 1995;3:171-195.
7Oyar O, Gülsoy UK. Tıbbi Görüntüleme Fiziği. Isparta, SDÜ Tıp; 2003:281-366.
8Blumberg HP, Charney DS, Krystal Jh. Frontotemporal neural systems in bipolar disorder. Semin Clin Neuropsychiatry. 2002;7:243-254.
9Chang K, Karchemskiy A, Barnea- Goraly N, Garrett A, Simeonova DI, Reiss A. Reduced amygdalar gray matter volume in familial pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2005;44:565-573.
10Pfeifer J, Welge J, Strakowski SM, Adler CM, DelBello MP. Meta-analysis of amygdala volumes in children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2008;47:1289-1298.
11Rosso IM, Cintron CM, Steingard RJ, Renshaw PF, Young AD, Yurgelun-Todd DA. Amygdala and hippocampus volumes in pediatric major depression. Biol Psychiatry. 2005;57:21-26.
12Liebenluft E, Rich BA. Pediatric bipolar diorder. Annu Rev Clin Psychol. 2008;4:163-187.
13Pavuluri MN, O’Conner MM, Haral E, Sweeney JA. Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. Biol Psychiatry. 2007;62:158-167.
14Botteron KN, Vannier MW, Geller B, Todd RD, Lee BC. Preliminary study of magnetic resonance imaging charecteristics in 8- to 16 - years olds with mania. J Am Acad Child Adolsc Psychiatry. 1995;34:742-749.
15DelBello MP, Adler CM, Strakowski SM. The neurophysiology of childhood and adolescent bipolar disorder. CNS Spectr. 2006;11:298-311.
16Kaufman J, Birmaher B, Brent D, ve ark. 1996, idKdie- SADS- Present and Lifetime Version 1.0, Çevirenler: Gökler B, Ünal F, Kültür Çengel SE, Pehlivantürk B, Akdemir D, Taner Y.
17Geller B, Zimerman B, Williams M, Bolhofner K, Craney JL, DelBello MP, Soutullo C. Reliability of the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) mania and rapid cycling sections. J Am Acad Child Adolesc Psychiatry. 2001;40:450-455.
18Wozniak J, Biederman J, Kiely K, Ablon JS, Faraone SV, Mundy E, Mennin D. Mania like symptoms suggestive of childhood onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry. 1995;34:867-876.
19Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56-62.
20Williams JB. A Structered interview guide for Hamilton Depression Rating Scale. Arch Gen Psychiatry. 1988;45:742-747.
21Akdemir A, Örsel SD, Dağ İ, Türkçarpar MH, İşcan N, Özbay H. Hamilton Depresyon Derecelendirme Ölçeği (HDDO)’nin geçerliliği-güvenilirliği ve klinikte kullanımı. Psikiyatri Psikoloji Psikofarmakoloji Dergisi. 1996;4:251-259.
22Young RC, Biggs JT, Ziegler VE, Meyer DA. Rating scale for mania: reliability and sensitivity. Br J Psychiatry. 1978;133:429-435.
23Karadağ F, Oral ET, Aran Yalçın F, Erten E. Young Mani Derecelendirme Ölçeğinin Türkiye’de geçerlik ve güvenirliliği. Türk Psikiyatri Dergisi. 2001;13:107-114.
24Frazier JA, Chiu S, Breeze JL, Makris N, Lange N, Kennedy DN, Herbert MR, Bent EK, Koneru VK, Dieterich ME, Hodge SM, Rauch SL, Grant PE, Cohen BM, Seidman LJ, Caviness VS, Biederman J. Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. Am J Psychiatry. 2005;162:1256-1265.
25Blumberg HP, Fredericks C, Wang F, Kalmar JH, Spencer L, Papademetris X, Pittman B, Martin A, Peterson BS, Fulbright RK, Krystal JH. Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disord. 2005;7:570-576.
26DelBello MP, Zimmerman ME, MillsNp, Getz GE, Strakowski SM. Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disord. 2004;6:43-52.
27Strakowski SM, DelBello MP, Sax KW, Zimmerman ME, Shear PK, Hawkins JM, Larson ER. Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Arch Gen Psychiatry. 1999;56:254-260.
28Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Arch Gen Psychiatry. 2003;60:1201-1208.
29Velakoulis D, Wood Sj, Hong MT, McGorry PD, Yung A, Phillips L, Smith D, Brewer W, Proffitt T, Desmond P, Pantelis C. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance study of chronic schizophrenia, first episode psychosis, and ultra-high-risk individuals. Arch Gen Psychiatry. 2006;63:139-149.
30Rosso IM, Killgore WD, Cintron CM, Gruber SA, Tohen M, Yurgelun-Todd DA. Reduced amygdala volumes in first episode bipolar disorder and correlation with cerebral white matter. Biol Psychiatry. 2007;61:743-749.
31Chen BK, Sassi R, Axelson D, Hatch JP, Sanches M, Nicoletti M, Brambilla P, Keshavan MS, Ryan ND, Birmaher B, Soares JC. Cross-sectional study of abnormal amygdala development in adolescent and young adults with bipolar disorder. Biol Psychiatry. 2004;56:399-405.
32Nugent AC, Milham MP, Bain EE, Mah L, Cannon DM, Marrett S, Zarate CA, Pine DS, Price JL, Drevets WC. Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry. NeuroImage. 2006;30:485-497.
Article is only available in PDF format. Show PDF
2024 ©️ Galenos Publishing House